[[1-(phenylmethyl)-1h-indazol-3-yl]oxy]acetic acid
bendazac
CAS: 20187-55-7
Molecular Formula: C16H14N2O3
[[1-(phenylmethyl)-1h-indazol-3-yl]oxy]acetic acid - Names and Identifiers
| Name | bendazac |
| Synonyms | bendazac BENDAZAC AKOS 90683 20187-55-7 BENDAZAC ACID bendazolic acid BENDAZAC AND ITS SODIUM SALT (1-BENZYL-1H-INDAZOL-3-YLOXY)-ACETIC ACID (1-Benzyl-1H-indazol-3-yloxy)-acetic acid [(1-Benzyl-1H-indazol-3-yl)oxy]acetic acid 2-(1-BENZYL-1H-INDAZOL-3-YLOXY)ACETIC ACID [[Benzyl-[1H]-indazol-3-yl] oxy] acetic acid [[1-(Phenylmethyl)-1H-indazol-3-yl]oxy]acetic Acid [[1-(phenylmethyl)-1h-indazol-3-yl]oxy]acetic acid acetic acid, 2-[[1-(phenylmethyl)-1H-indazol-3-yl]oxy]- |
| CAS | 20187-55-7 |
| EINECS | 243-569-2 |
| InChI | InChI=1/C16H14N2O3/c19-15(20)11-21-16-13-8-4-5-9-14(13)18(17-16)10-12-6-2-1-3-7-12/h1-9H,10-11H2,(H,19,20) |
| InChIKey | BYFMCKSPFYVMOU-UHFFFAOYSA-N |
[[1-(phenylmethyl)-1h-indazol-3-yl]oxy]acetic acid - Physico-chemical Properties
| Molecular Formula | C16H14N2O3 | |||
| Molar Mass | 282.29 | |||
| Density | 1.1658 (rough estimate) | |||
| Melting Point | 161-163°C | |||
| Boling Point | 424.91°C (rough estimate) | |||
| Flash Point | 261.1°C | |||
| Solubility | DMSO (Slightly), Methanol (Slightly, Heated) | |||
| Vapor Presure | 3.78E-11mmHg at 25°C | |||
| Appearance | White to off-white crystalline powder | |||
| Color | Crystals from ethanol | |||
| Maximum wavelength(λmax) | ['306nm(lit.)'] | |||
| Merck | 14,1035 | |||
| pKa | 2.89±0.10(Predicted) | |||
| Storage Condition | Sealed in dry,Room Temperature | |||
| Refractive Index | 1.6240 (estimate) | |||
| Physical and Chemical Properties |
| |||
| Use | Used as an anti-inflammatory analgesic | |||
| In vitro study | Bendazac is an anti-inflammatory agent endowed with protein antidenaturant properties effective for various inflammatory skin conditions. Bendazac has been shown to be a strong reacting substrate in a chemical oxidizing system, which mimics a physiological pathway of hydroxy radical generation. By using EPR spectroscopy of spin-labelled bovine serum albumin (BSA), Bendazac was shown to prevent the BSA denaturation induced by urea, heat and free radicals produced in the xanthine/xanthine oxidase system. |
[[1-(phenylmethyl)-1h-indazol-3-yl]oxy]acetic acid - Risk and Safety
| RTECS | AF5085000 |
| Toxicity | LD50 in mice, rats (mg/kg): 380, 304 i.v.; 355, 388 i.p.; 440, 910 s.c.; 1105, ~1200 orally (Rx Bulletin) |
[[1-(phenylmethyl)-1h-indazol-3-yl]oxy]acetic acid - Reference Information
| biological activity | Bendazac is an oxyacetic acid with anti-inflammatory, anti-allergic, choleretic and anti-lipid properties. Bendazac prevent protein denaturation and delay the occurrence of cataract. |
| Use | Used as an anti-inflammatory analgesic Pharmaceutical |
| category | toxic substances |
| toxicity classification | poisoning |
| acute toxicity | oral-rat LD50: 1200 mg/kg; Oral-mouse LD50: 1105 mg/kg |
| flammability hazard characteristics | combustible; combustion produces toxic nitrogen oxide smoke |
| storage and transportation characteristics | ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
Last Update：2024-04-09 18:58:34
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